There are a number of studies supporting the efficacy of medical cannabis in eliminating nausea, appetite loss and other HIV/AIDS related. HIV/AIDS and Medical Cannabis. Recent studies have found that medical cannabis is effective in treating the symptoms caused by HIV/AIDS. The experience of patients, medical professionals and research has revealed that cannabis can safely treat a remarkably broad range of medical conditions.
Medicinal – HIV Cannabis Research AIDS
This means that the conclusions drawn from such studies are suggestive, not definitive. Observational studies are a good starting point to explore a potential biomedical issue and collect data that can be used to develop a study of a more robust design.
Researchers are aware of the issues that affect observational study designs but have to develop a body of evidence that can later be used to support the need for larger and more robustly designed studies. Such robust studies are expensive and take time to develop, must compete against other research proposals for limited funding and then, if funded, have to be executed.
These processes take time and it could take five to 10 years for such studies to bear fruit. It is noteworthy that while marijuana or its extracts may have beneficial effects on the immune systems of HIV-positive people, it is possible that in some cases marijuana may have harmful effects as well. For instance, the smoke from burning marijuana contains a mix of compounds somewhat similar to that produced when tobacco is burned.
It is therefore possible that people who chronically smoke marijuana may increase their risk for cardiovascular and lung disease.
The point about marijuana and cardiovascular disease is explored later in this issue of TreatmentUpdate. Also explored later in this issue of TreatmentUpdate: Marijuana can also interfere with the immune system by weakening some aspects of its ability to carry out its functions.
Will this weakening have any negative health consequences? Future studies need to pay attention to these and the following issues:. Programming Connection case study: De-simplifying single-tablet regimens for HIV treatment. Prevention in Focus Insufficient food linked to inflammation in HIV-positive women. Request for Proposal RFP: Production of this Web site has been made possible through a financial contribution from the Public Health Agency of Canada.
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CATIE ensures that these resources, developed to help prevent the transmission of HIV, hepatitis C and other infections, are written and reviewed by health experts for content accuracy. Jump to Navigation Jump to Content. Hepatitis C Subscriptions Become a Member. See all issues of TreatmentUpdate Subscribe. Some research issues with marijuana, HIV and inflammation. Inflammation and immune activation in general When cells of the immune system discover the presence of an invading microbe or tumour, a normal response is to mobilize the rest of the immune system.
Inflammation and immune activation with HIV Chronic HIV infection is associated with excessive levels of inflammation and activation of the immune system. Researchers are concerned that chronic HIV-related inflammation and immune activation may, over the long-term, contribute to an increased risk for the following conditions: Marijuana and HIV Most of the studies done with herbal marijuana as opposed to pharmacological preparations or extracts in people with HIV have not been robustly designed.
Cannabinoids and the immune system—a possible point of intervention Lab experiments with cells of the immune system have found that when these cells become activated they display a relatively high density of receptors for cannabinoids. Bear in mind As mentioned earlier, the vast majority of studies with herbal marijuana and HIV-positive people have been observational in nature. Future studies need to pay attention to these and the following issues: Which strains of marijuana were used?
What was the relative mix of cannabinoids in such strains? How was marijuana used—smoked, ingested edibles or vapourized? How much marijuana was used and how often? Are there differences in the effect of marijuana by gender?
The lymph node in HIV pathogenesis. Rapid inflammasome activation following mucosal SIV infection of rhesus monkeys. Multiple origins of virus persistence during natural control of HIV infection. HIV-infected macrophages and microglia that survive acute infection become viral reservoirs by a mechanism involving Bim.
Immunologic biomarkers, morbidity and mortality in treated HIV infection. Journal of Infectious Diseases. Persistent HIV-1 replication maintains the tissue reservoir during therapy. Defining total-body AIDS-virus burden with implications for curative strategies. Gut epithelial barrier and systemic inflammation during chronic HIV infection.
T-cell activation independently associates with immune senescence in HIV-infected recipients of long-term antiretroviral treatment. Suboptimal adherence to combination antiretroviral therapy is associated with higher levels of inflammation despite HIV suppression. Ageing and inflammation in patients with HIV infection. Clinical and Experimental Immunology. Mamik MK, Power C. Inflammasomes in neurological diseases: Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection.
Association of arterial and lymph node inflammation with distinct inflammatory pathways in human immunodeficiency virus infection. Endocannabinoid system acts as a regulator of immune homeostasis in the gut. More and more studies are surfacing that show just how important cannabis may be for the treatment of HIV.
Support for medicinal marijuana has reached an all-time high in the United States. People with HIV have long realized that cannabis can ease many HIV-related conditions, including nausea, loss of appetite, depression, weight loss, and neuropathic pain. In addition to treating common symptoms of HIV and side effects of antiretroviral drugs, research indicates that cannabis may help fight HIV itself.
An increasing number of scientific studies, conducted at well-known institutions and published in prominent medical journals, are revealing antiviral effects of cannabis against HIV. These studies detail diverse approaches in measuring favorable effects that cannabis may have in slowing HIV disease progression. By stimulating activation of CB2 with cannabinoid receptor antagonists, Mount Sinai researchers decreased the ability of HIV to infect cells that utilize CXCR4, reducing the frequency of infected cells by 30 to 60 percent.
Cannabinoids may help prevent neurocognitive disorders Research conducted at Temple University School of Medicine and published in the Journal of Leukocyte Biology suggests that compounds that stimulate CB2 on macrophages may weaken HIV infection. CB2 is the binding site for cannabinoids on macrophages, and stimulation of these receptors, unlike CB1, does not produce the euphoric effects associated with cannabis use. Neurocognitive disorders are common in people with HIV even in the presence of a strong immune response and suppressed viral load.
The virus establishes itself in the central nervous system early on in HIV infection and maintains a stronghold throughout the course of disease.
How Does Marijuana Affect People With HIV?
In many ways, the progress of modern cannabinoid medicine has its roots in According to amfAR, the Foundation for AIDS Research. Get information on prevention, symptoms, and treatment to better ensure a long and Research Supporting Marijuana in Treating HIV Wasting. book on the history of the medical marijuana movement. litical prowess of AIDS activists and the frustrations of AIDS researchers had a profound effect on.