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    Difenoxin with atropine Motofen has drugs. Without atropine, these drugs are in Schedule II. That bill was then super- seded by the Combat Methamphetamine Epidemic Act of , which was passed as an amendment to the Patriot 1. Raich [9] The Act: Oakland Cannabis Buyers' Cooperative [15]. Cato Handbook for Congress: It is an eclec- Archive copy at the Wayback Machine tic concept having only one uniform connotation: A Modern History vey on Drug Abuse. Their Derivatives [27] 21 U. Federal Register Drug ica: Clinical Toxicology 46 9: Clinical Toxicology 35 6: Drug harms in the UK: A multicriteria decision doi: The Lancet, , Retrieved 30 October Retrieved 3 September The most notable cannabinoid is the phy- doi: The botany and CBD is another major constituent of the plant.

    CB1 re- ceptors are absent in the medulla oblongata, the part of the brain stem responsible for respiratory and cardiovascular functions.

    Cannabinoid receptor type 2 Main article: While found only in the peripheral nervous system, a report does indicate that CB2 is ex- pressed by a subpopulation of microglia in the human cerebellum.

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    CBD has been shown to play a role in preventing the short-term memory loss as- Biosynthesis Cannabinoid production starts when an sociated with THC. For the propyl homo- chosis. Trials indicated it was safe and well tolerated. Cannabis plants can exhibit wide variation in the quantity and type of cannabinoids they produce.

    Selective breeding has been used to position of the double bond in the alicyclic carbon ring. Under the dibenzopyran numbering system choactive chemicals like THC.

    Liquid chromatography LC techniques are also pounds. There have to the aromatic ring. In the most common of cannabis over time, but their accuracy is impeded by the homologue, the pentyl chain is replaced with a propyl 3- illegal status of the plant in many countries. Pharmacology Cannabinoids can be administered by smoking, vaporiz- ing, oral ingestion, transdermal patch, intravenous injec- Cannabinoids in other plants tion, sublingual absorption, or rectal suppository.

    Once in the body, most cannabinoids are metabolized in the liver, Phytocannabinoids are known to occur in several plant especially by cytochrome P mixed-function oxidases, species besides cannabis. Hydrocarbons and alcohols are often Most of the phytocannabinoids are nearly insoluble in wa- used as solvents.

    Butane may be used, which evap- organic solvents. Due to molecular similarity and ease of synthetic conver- All of these are members of a family of signalling sion, CBD was originally believed to be a natural precursor lipids called N-acylethanolamines, which also includes to THC.

    Arachidonoylethanolamine nal immobility, and mild antinociception in mice. It binds primarily to the CB1 receptor, and only weakly to the CB2 receptor. Anandamide is derived from N-Arachidonoyl dopamine arachidonic acid. Activation of cannabinoid receptors temporar- for the vanilloid receptor subtype 1 TRPV1 , a member of ily reduces the amount of conventional neurotransmitter re- the vanilloid receptor family. Virodhamine cell depends on the nature of the conventional transmit- ter being controlled.

    Al- is an increase in the excitability of the endocannabinoid- though it is a full agonist at CB2 and a partial agonist at releasing cell. On the converse, when release of the ex- CB1 , it behaves as a CB1 antagonist in vivo. In rats, virod- citatory neurotransmitter glutamate is reduced, the net ef- hamine was found to be present at comparable or slightly fect is a decrease in the excitability of the endocannabinoid- lower concentrations than anandamide in the brain, but 2- releasing cell.

    Lysophosphatidylinositol LPI Recent evidence has They cannot travel unaided for long distances in the aqueous highlighted lysophosphatidylinositol as the endogenous lig- medium surrounding the cells from which they are released, and to novel endocannabinoid receptor GPR55, making it and therefore act locally on nearby target cells.

    Hence, al- a strong contender as the sixth endocannabinoid. Function Endocannabinoids serve as intercellular 'lipid messengers', 1. Although in this intercellular signaling role they are similar to the well-known monoamine neurotransmitters, Historically, laboratory synthesis of cannabinoids were of- such as acetylcholine and dopamine, endocannabinoids dif- ten based on the structure of herbal cannabinoids, and a fer in numerous ways from them.

    For instance, they are large number of analogs have been produced and tested, used in retrograde signaling between neurons. Further- especially in a group led by Roger Adams as early as more, endocannabinoids are lipophilic molecules that are and later in a group led by Raphael Mechoulam. Newer not very soluble in water. They are not stored in vesicles, compounds are no longer related to natural cannabinoids and exist as integral constituents of the membrane bilay- or are based on the structure of the endogenous cannabi- ers that make up cells.

    They are believed to be synthe- noids. The mechanisms and enzymes underlying the biosynthesis Synthetic cannabinoids are particularly useful in exper- of endocannabinoids remain elusive and continue to be an iments to determine the relationship between the struc- area of active research.

    Endocannabinoids, on the other Medications containing natural or synthetic cannabinoids or hand, are described as retrograde transmitters because they cannabinoid analogs: Pharmacological Reviews 58 3: CB1 receptor inverse agonist once used as an anti- doi: It [2] Lambert, Didier M.

    Journal of Medic- inal Chemistry 48 Other notable synthetic cannabinoids include: Journal of Natural Products 79 2: Retrieved 6 June A Cellular and Molecular Approach. Progress in Lipid Research 50 2: European Journal of Biochemistry 6: US Patent application number: Some physical and chemical fea- Bulletin on narcotics 32 2: Schizophrenia Research American Journal of Botany 91 6: British Journal of Pharmacol- ogy 7: Neurochemical Research 30 8: Behavioural Pharmacology 16 5—6: The Journal of Pharmacol- [28] http: Retrieved 6 October Journal of Medicinal Chemistry 43 Planta Medica 63 1: British Journal of Pharmacology 1: Journal of Chromatography A 2: Plant Physiology 4: The plant-derived yangonin is a novel CB1 recep- Pharmacological Research 66 2: Drug Metabolism Reviews 46 1: Pro- [39] Ashton CH February Br J Psychiatry 2: They are then slowly released back into other body Mayumi; Suhara, Yoshitomo; Takayama, Hiroaki; Waku, compartments, including the brain.

    They are then slowly Keizo; Sugiura, Takayuki Journal nation half-life of THC is about 7 days, and complete elim- of Neurochemistry 85 6: Annual Review of Neu- Yu. Novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with [41] Grotenhermen, Franjo Life Sciences 65 6—7: Life Sciences 78 macology and Experimental Therapeutics 3: Journal of Medicinal Chem- istry 36 Update on Chemistry, new cannabinoid acids from Cannabis sativa L.

    Med can Journal of Drug and Alcohol Abuse 0 0: Drug and Chemical Schatz, Anthony R. Oc- cal Pharmacology 50 1: Journal of Neuroscience 28 Science Rehnelt, J. In , the binding of several cannabinoids Journal of Natural Products 44 1: Cannabinoids bind reversibly and stereo-selectively to the cannabinoid receptors. Subtype se- lective cannabinoids have been developed which theoreti- cally may have advantages for treatment of certain diseases 1.

    Cannabinoid receptor type 1 Cannabinoid receptor type 1 CB1 receptors are thought to be one of the most widely expressed G protein-coupled receptors in the brain. This is due to endocannabinoid- mediated depolarization-induced suppression of inhibition, a very common form of short-term plasticity in which the depolarization of a single neuron induces a reduction in GABA-mediated neurotransmission. Endocannabinoids released from the depolarized post-synaptic neuron bind to CB1 receptors in the pre-synaptic neuron and cause a re- CB1 and CB2 structures.

    Cannabinoid receptors, located throughout the body, are They are also found in other parts of the body. For instance, part of the Endocannabinoid system which is involved in a in the liver, activation of the CB1 receptor is known to in- variety of physiological processes including appetite, pain- crease de novo lipogenesis. A study suggested that the endocannabinoids and their Cannabinoid receptors are of a class of cell membrane cannabinoid receptors play a major role during pre- and receptors under the G protein-coupled receptor superfam- postnatal development.

    All of the endo- 1. Cannabinoid receptor type 2 There are currently two known subtypes of cannabinoid re- ceptors, termed CB1 and CB2. The CB2 hematopoietic cells. They also have a function in receptor is expressed mainly in the immune system and in keratinocytes.

    They are also expressed on peripheral nerve hematopoietic cells. In the brain, they are mainly expressed and non-CB2 , which are expressed in endothelial cells and by microglial cells, where their role remains unclear.

    This ef- through activation of GPR Sub- sequent studies showed that GPR55 does indeed respond to cannabinoid ligands.

    CB2 is expressed erated naturally inside the body endocannabinoids or in- in osteoblasts, osteocytes, and osteoclasts. CB2 agonists en- troduced into the body as cannabis or a related synthetic hance endocortical osteoblast number and activity while re- compound.

    PMID Several synthetic cannabinoids have been shown to bind to One of the described compounds, a classical TI THC-type cannabinoid, L,, in which the phenolic —4. Certain tumors, especially gliomas, express CB2 receptors. PMID and smoking cessation see Rimonabant. CB1 provides neuroprotection after brain injury. Journal of Molecular Modeling 17 9: Prostaglandins Other Lipid Mediat.

    Addict Biol 13 2: J Am Coll Cardiol. PMID tive stress and cell death in murine models of doxorubicin- Free Radic Biol Med. Drug [33] Gaoni Y, Mechoulam R International Union of Basic doi: Not to be confused with cannabinol or cannabinodiol. Retrieved 11 June It is a catastrophic form of intractable epilepsy that begins in infancy.

    Epidiolex was granted fast- track status and is in late stage trials following positive 1. At room temperature, it is a col- receptors but acts as an indirect antagonist of their orless crystalline solid. FEBS Letters Nagaraja, Kodihalli Nanjappa, Synthesis of delta- are considered hemp, or considered marijuana.

    Tetrahydrocannabinol Isomerism, Abnormal cannabis. Non-psychoactive hemp also commonly-termed cannabidiol. UK Cannabidiol, in an oral-mucosal spray formulation Soc.

    PMID tion product available for relief of severe spasticity due to Epilepsia Review 55 6: Retrieved 15 December Phytother Res [14] Angus, Chen 8 December Retrieved 14 December Retrieved 7 January PMID Free full text Iwasaki K, Fujiwara M March Naunyn-Schmiedeberg's Archives of Pharmacology 5: Drug Metabolism and Disposition 23 8: British Journal of Pharmacology 7: PMID ogy 2: Joca SR January Statement on a non- cannabidiol in mice: Retrieved 21 July Tetrahedron Letters 26 8: Journal of Experimental Botany 60 Not to be confused with cannabidiol or cannabinodiol.

    Cannabinol CBN is a weak psychoactive cannabinoid found only in trace amounts in Cannabis sativa and [49] Fournier, G. CBN is then formed by de- doi: Journal of Medic- inal Chemistry 43 Cannabis drug and Hemp [2] David R.

    They can also be used as caged-bird feed, as they provide a moder- [3] Sigma-Aldrich Co. A Cannabis plant in the vegetative growth phase of its life requires more than 12—13 hours of light per day to stay veg- etative. Flowering usually occurs when darkness equals at least 12 hours per day. In soil, the optimum pH for the plant is 6. In hydroponic growing, the nutrient solution is best at 5.

    A nominal if not legal distinction is often made between industrial hemp, with concentrations of psy- and ointments have also been common preparations. In choactive compounds far too low to be useful for that traditional medicine of India in particular C. Male plants shed their pollen and die several weeks prior to seed ripening on the female plants. Although genetic factors dispose a plant to become male or female, environmental factors includ- ing the diurnal light cycle can alter sexual expression.

    These are mainly volatile terpenes and sesquiterpenes. THC ratios are less likely to induce anxiety than vice versa. Synthetic THC, called dronabinol, cannabis. Re- trieved 28 May Cannabis and Cannabinoid Research 1 1: Drug Testing and Analysis 4 Journal of Industrial Hemp 8 2: Botanical Gazette 71 Retrieved 28 May Flavour and Fragrance Journal 16 4: Cannabis indica, formally known as Cannabis sativa forma indica, is an annual plant in the Cannabaceae family.

    Indica strains tend to have wide, short leaves with indica. Lamarck based his description of the newly named short wide blades, whereas sativa strains have long leaves species on plant specimens collected in India.

    Richard with thin long blades. The buds of indica strains tend to be Evans Schultes described C. Schultes's and Anderson's descriptions may have originated from the Hindu Kush mountain range. These are merely comparative values, we must not in- summers climate of those parts, C.

    The reverse is generally true with a ratio of CBD being aver- age in most cannabis strains. The medical interests in Bangladesh and Pakistan are traditionally cultivated for Cannabis are taking this further and we will see more strains the production of charas.

    THC ratios are nia and an anxiolytic, as opposed to sativa's more common less likely to induce anxiety than vice versa. Users can ex- and Northern Lights. This is mainly because of the higher CBD: Marijuana Grower's Handbook Ask 1. Phytochemistry 71 1.

    Harvard University Botanical Archives, , p. Harvard Uni- Police Science and Administration, , p. Retrieved 30 May Phytochemistry 71 Biology 12 Morocco Rif on geopium. Amsterdam Marijuana Seeds Seed Bank. Cannabis ruderalis is a species of Cannabis originating in central Russia. It is less common than the other species of [8] McPartland, J. Without human selection, these plants 1. Retrieved 15 July Berke- early s in order to enhance the breeding program of ley, California: Cannabis ruderalis has a lower THC content than either C.

    A World sativa or C. Cannabis ruderalis strains are high pp. Cannabis Culture medical marijuana users. Retrieved 16 February The Cannabis Breeder's Bible: Green Candy reputed resistance to insect and disease pressures makes it Press. An Ad- vanced Study. Cannabis Culture Mag- azine. Dutch Passion Seed Company. Re- trieved 15 July This all depends on the Hashish Trail, only small pieces of Lebanese hashish were process and amount of solvent left over. It is believed that massive hashish pro- Northern India has a long social tradition in the production duction for international trade originated in Morocco dur- of hashish, known locally as charas, which is believed to ing the s, where the cannabis plant was widely avail- be the same plant resin as was burned in the ceremonial able.

    He particularly mentioned the Egyptian Hashish. At around the same time, American author Fitz Hugh Ludlow wrote the book The Hasheesh Eater about his youthful experiences, both positive and negative, with the drug. The resulting powder, referred to 1. Ice-water separation is an- male plant contain the most trichomes, though trichomes other mechanical method of isolating trichomes. The clar- are also found on other parts of the plant. Nowadays, new techniques have been developed, such duce large amounts of trichomes.

    The resin reservoirs of as heat and pressure separations, static-electricity sieving or the trichomes, sometimes erroneously called pollen ven- acoustical dry sieving. John Huyghen van Linschoten to the East Indies. Full text at Internet Archive. This leaves most of the glands intact. Drugs, behavior, and modern soci- In a study conducted in by Jean-Jaques Fil- ety. The War on Drugs II. World They are of diverse structure and function. Examples are [4] Hashish! A covering of any kind of hair on a plant is an indumentum, and the sur- [5] Merlin, M.

    Table 1 re Taiwan and p. The same term is applied to such structures in Atibba, Berkeley: University of California Press, Sticky trichomes of a carnivorous plant, Drosera capensis with a 1. Aerial surface hairs Trichomes on plants are epidermal outgrowths of various kinds.

    The terms emergences or prickles refer to out- growths that involve more than the epidermis. This distinc- tion is not always easily applied see Wait-a-minute tree. Also, there are nontrichomatous epidermal cells that pro- trude from the surface. A common type of trichome is a hair. Plant hairs may be unicellular or multicellular, branched or unbranched.

    Multicellular hairs may have one or several layers of cells. Branched hairs can be dendritic tree-like as in kangaroo paw Anigozanthos , tufted, or stellate star-shaped , as in Arabidopsis thaliana.

    Another common type of trichome is the scale or peltate hair, that has a plate or shield-shaped cluster of cells at- tached directly to the surface or borne on a stalk of some kind. Common examples are the leaf scales of bromeliads such as the pineapple, Rhododendron and sea buckthorn Trichomes on Cannabis, rich in cannabinoids.

    Any of the various types of hairs may be glandular, pro- In describing the surface appearance of plant organs, such ducing some kind of secretion, such as the essential oils as stems and leaves, many terms are used in reference to the produced by mints and many other members of the fam- presence, form, and appearance of trichomes.

    The most ba- ily Lamiaceae. However, several basic functions or advantages of having surface hairs can be listed. Hairs on plants growing in areas subject to frost keep the frost away from the living surface cells. In ad- dition, in locations where much of the available moisture comes from fog drip, hairs appear to enhance this process. Root hairs Root hairs, the rhizoids of many vascular plants, are tubu- Epidermis of Arabidopsis thaliana with a trichome.

    That is, root hairs are lateral ex- tensions of a single cell and only rarely branched. Details are provided by: Root hairs can sur- 1.

    At the same time new root hairs are continually being formed at the top Plants may use trichomes in order to deter herbivore attack of the root. This way, the root hair coverage stays the same. However, some or- most part. This is why planting out may cause plants to wilt.

    Principles of an- giosperm taxonomy. Journal of the Foren- sic Science Society 13 3: Journal of The Royal Society Interface 10 Frontiers in Ecology and Evolution 2.

    Her- European wool carder bee Anthidium manicatum. This bivore Handling of a Plant's Trichome: The Case of Helico- bee species incorporates trichomes into their nests by scrap- nius Charithonia L. Plant Anatomy, 2nd Edition. For recre- ational marijuana, see Cannabis drug. For other uses, see Hemp disambiguation. Then it ap- textiles, clothing, biodegradable plastics, paint, insulation, pears to have been borrowed into Latin, and separately into biofuel, food, and animal feed.

    However, this theory assumes that hemp tions and uses. When oxidized commonly referred Nutrition Further information: They Hemp seeds have been used in bird feed mix as well.

    The leaves of the hemp for dehulled hemp seed. Hemp can also be made into a liquid and used for baking or for beverages such Hemp seeds are a rich source of B vitamins, the dietary as hemp milk, hemp juice, and tea.

    Completed in , The Renewable House is one of the most techno- logically advanced made from hemp-based materials. Hemp plaster has insulative qualities. Various car mak- Concrete-like blocks made with hemp and lime have been ers are beginning to use hemp in their cars, including used as an insulating material for construction.

    Another issue paper, made from hemp, dates to the early Western Han is that the entire hemp plant cannot be economically pre- Dynasty, two hundred years before the nominal invention of pared for paper production. Hemp pulp is bleached with hydrogen peroxide, a pro- The Saint Petersburg, Russia, paper mill of Goznak opened cess today also commonly used for wood pulp.

    It used hemp as its main input material. The market is considered saturated with little or no growth in this area. Hemp jewelry Hemp jewelry is the product of knotting hemp twine Hemp rope. Hemp and bead Jewelry. Hemp jewellery in- cludes bracelets, necklaces, anklets, rings, watches and other adornments. Some jewellery features beads made from glass, stone, wood and bones. The hemp twine varies in thickness and comes in a variety of colors.

    Hemp rope was phased out when Manila, which animal bedding horses, for instance , or for horticultural does not require tarring, became widely available. Additionally Hemp is being used to clean con- taminants at the Chernobyl nuclear disaster site.

    By way of a process which is known as phytoremediation - the process of clearing radioisotopes as well as a variety of other toxins from the soil, water, and air. Due to its rapid, dense growth characteristics, in some jurisdictions hemp is considered a prohibited noxious weed, much like Scotch Broom.

    Biofuels Biodiesel can be made from the oils in hemp seeds and stalks and alcohol fuel ethanol or, less commonly, methanol from the fermentation of the whole plant. Production of vehicle fuel from hemp is very small. HEMP 99 would perform very poorly as sources of drug material. Today, however, the common perception of the industrial hemp plant is generally negative and associated with the drug marijuana. Hemp needs less fertilizer than corn does.

    Organic fertilizers such as manure can utilize industrial hemp well. Neither weeds nor crop protection measures are necessary. Typically, hemp contains Cannabis sativa L. Mechanical harvesting is now common, using specially amounts of this psychoactive drug, not enough for any phys- adapted cutter-binders or simpler cutters.

    Water logged acidic, compressed or extremely light suited for industrial hemp, but it also has medicinal varieties. Steep and high altitudes of more than m above sea level are best avoided. Seeds can germinate down to degrees. Hemp needs a lot of heat, so earlier varieties come to maturation.

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