Cannabis topicals are a great way to enjoy the benefits of THC and CBD Before applying your cannabis ointment, consider where your pain is coming from. For example, if you're getting a tension headache, applying a CBD topical to your neck could be beneficial. Figuring out exactly what's causing. CBD topicals can be an effective treatment for many symptoms. Once applied, they can take anywhere from one to 48 hours to provide relief.
topicals Applying CBD
A study published in the British Journal of Pharmacology found that CBD controls cell proliferation and differentiation , indicating it can be used in treatment efforts for skin diseases like allergies or cancer. Besides the natural health benefits of CBD, hemp oil topicals also contain an array of other essential nutrients, including vitamins, minerals, proteins, and fatty acids, to encourage skin health.
Vitamins A and D are responsible for skin repair. They support skin cell growth and inhibit oil production to help keep skin soft and supple. B complex vitamins serve as part of the construction process for skin, hair and nails to prevent dermatitis, hair loss, and other skin conditions. Ingesting CBD products orally causes CBD and other compounds to enter the blood stream, which elicits full-body effects and takes up to 2 hours or more before those effects are experienced.
With CBD topicals, the healing compound and other hemp-derived nutrients are almost immediately absorbed directly through your skin, allowing them to be target the affected area for quicker and more focused effects. You can learn more about CBD and hemp oil by visiting our Education page. We also recommend these articles:. Are you on social media? Federal Tax ID The information contained in this website is for general information and educational purposes only. Nociceptive behaviour, potential adverse side-effects and inflammation-associated anatomical changes in knee joint and neuronal tissue were assessed.
All animal procedures were approved by the University of Kentucky IACUC committee and were conducted according to guidelines for the ethical treatment of experimental animals published by the Internal Association for the Study of Pain.
A total of 54 rats were used in the experiments described here of which 21 were used as naive controls and 23 were subjected to adjuvant-induced arthritis. Rats were returned to their home cages and monitored daily. Joint circumference and pain-related behaviours were assessed prior to CFA injection and daily beginning on day 3 after CFA days 3—7. All gels, including vehicle controls, were prepared by weighing the desired amount of CBD gift from NIDA and dissolving it in ethanol Gels were then sonicated for 10 min, loaded into 1 mL syringes and sealed.
Gels made just prior to the initial dosing were used for the entire week since no degradation was observed and plasma CBD concentration remained constant. Hindlimbs were fully extended while the circumference of the knee joint was determined using a flexible tape measure wrapped around the centre of the joint. Measurements were taken on day 0, 3 and 7. A subjective pain-related behavioural scale was used Sluka et al.
Hindpaw heat sensitivity was assessed prior to CFA injection as well as daily starting on day 3 after inflammation, 4 h after each gel application. Paw withdrawal latency PWL was measured as described in our previous study Zhang et al. Maximal cut-off time for paw withdrawal reflex was set at 15 s to avoid skin damage. Both hindpaws were tested independently for 5 trials at 5 min intervals by an examiner blinded to the treatment group.
The area of gel application and volume used corresponded to the calculated final dose of CBD, i. Joint inflammation and nociceptive behaviour were assessed starting 4 h after gel application. Plasma concentration of transdermally absorbed CBD was determined. As described by Paudel et al. The ZQ detector was used with an electrospray ionization probe set for single ion monitoring for CBD quantification.
Capillary and cone voltage were set at 35 kV and 40 V, respectively. Nitrogen was used as nebulization flow rate: The mobile phase was comprised of Spinal cord sections were stained using monoclonal mouse anti-OX 1: Controls included the absence of staining upon omission of the primary antibody and the side to side differences between the ipsilateral and contralateral sides as internal controls.
Synovial membrane thickness was measured by drawing a perpendicular line from the outer surface to the inner margin of the intimal layer of the synovial membrane in two places within each section and averaging their length Cunnane et al. Immunostaining of fluorescent labelled tissue was visualized using a Nikon Eclipse E microscope equipped with a Cool Snap photometric Camera ES and analysed off-line with MetaMorph software. Camera settings were kept constant within an antibody staining to quantify and compare immunoreactivity.
Images of the dorsal horn were analysed by outlining the substantia gelatinosa, determining and averaging the mean intensity of staining in this region.
Background fluorescent intensity was measured outside of this area and subtracted. DRG sections were sampled by drawing regions of interest over five randomly selected sensory neuron somas, measuring the mean intensity and averaging for each animal sampled. Histological analysis was conducted in the four experimental groups: Mean intensities were averaged and compared across treatment groups.
GraphPad Prism version 6. Animals were treated with CBD gel in four different doses: After four consecutive days of treatment, plasma CBD concentrations in all rats were 3. However, CBD plasma concentrations after application of the Daily applications of 6.
Assessment of knee joint inflammation. A Ipsilateral knee joint circumference was significantly increased in rats with adjuvant-induced monoarthritis and significantly decreased after four consecutive days of transdermal cannabidiol CBD treatment using 6. B Pain scores median were maximal 3 days after adjuvant-induced monoarthritis and were significantly reduced by 6. F Bar graph shows high doses of CBD combined 6. Transdermal application of 6.
Limb posture scores as a rating of spontaneous pain were high on day 3 median score 4 in all animals with adjuvant-induced monoarthritis.
On day 7, after 4 days of transcutaneous treatment with 6. Pain scores of animals that received 0. All naive rats scored 0 in this test. Baseline paw withdrawal latencies were similar in all experimental animals 10—12 s. Hypersensitivity to noxious heat was detected in all animals with adjuvant-induced monoarthritis.
Average paw withdrawal latency PWL in response to radiant heat applied to the plantar surface of the same side hindpaw, was significantly decreased on day 3 from After 2 days of treatment with 6. Reduction in monoarthritis-induced heat hypersensitivity was maximal after 2 days of transdermal application of 6.
Adjuvant-induced heat hypersensitivity was not changed by transdermal application of vehicle, nor by 0. Daily application of CBD gel on naive animals did not alter heat sensitivity irrespective of the concentration used Fig. Transdermal cannabidiol CBD reduced monoarthritis-induced hind paw heat hypersensitivity.
C, D In the open-field test, transdermal CBD exerts no detectable effect on times spent in spontaneous exploratory activity or resting. Potential for adverse side-effects on activity levels or motor abilities stemming from CBD gel application were assessed by monitoring open-field exploratory behaviour of naive animals for 45 min prior to and directly after treatment. Irrespective of the amount of CBD applied onto the back of animals, no changes were detected for total time spent in either exploratory activity or resting Fig.
Two other specific exploratory activities acquired in the open-field test but not affected by CBD were rearing events in which the animals rise on their hindlimbs to explore the environment and the total distance travelled during the 45 min test data not shown.
After batch staining immunohistochemical methods, the intensity of immunofluorescence was determined using computer assisted quantification. The immunoreactivity for neuropeptide CGRP was significantly increased in the superficial dorsal horn of the spinal cord in the monoarthritis group. Treatment with high doses of CBD 6. Immunocytochemical localization of inflammatory biomarkers.
Quantification of pro-inflammatory biomarkers in the lumbar spinal cord and dorsal root ganglia DRG. Naive animals had low levels of OX42 expression in the spinal cord, a marker for activated microglia Fig. Outcomes of this study indicate that topical application of CBD gel is an effective treatment for reduction in inflammation and hypersensitivity associated with the rodent adjuvant-induced monoarthritis model.
Transdermal administration of CBD provided good blood absorption due to avoidance of first pass metabolism encountered by orally administered drugs. Similarly in this study, CBD plasma concentrations for rats dosed with 0. However, the highest dose, The lack of increased outcome for this highest CBD concentration was potentially due to maximally activated CBD effects or capacity-limit absorption and metabolism. This would account for the flattened linear pharmacokinetic profile effect of the Spreading large quantities of gel directly on the skin over the joint itself was not feasible in this transdermal dosing paradigm and would provide opportunity for oral ingestion by the rats.
Efficacy of transdermal CBD for reduction in inflammation-associated symptoms in adjuvant-induced monoarthritic animals was determined comparing knee joint circumference and other features. Likewise, increased synovial membrane thickness was reduced by the 6. These results concur with previous studies showing orally administered CBD decreased inflammation Malfait et al.
Decreased inflammation and reduction in secretions of pro-inflammatory and matrix-degrading effector molecules by the synovial cell connective tissue membrane lining the joints are important for symptomatic treatment of patients with rheumatoid arthritis.
Pro-inflammatory and matrix-degrading effector molecules produced in excess are primary contributors to cartilage degradation over time Ospelt et al. The improvement of pain scores provided by transdermal CBD is an indirect measure of joint inflammation and direct measure of function. The PWL in response to noxious heat stimuli was optimal with both the 6.
Analogous to the results presented here, the highest dose of CBD administered in that study also did not perform as well as the next lower dose. In the same study at 6 h post inflammation, CBD treatment with two orally administered lower doses, 5 and 7. Peripheral inflammation and hypersensitivity are reversed by pharmacological inactivation of both central and peripheral neurons and central microglia Sluka et al.
Although CBD is described as an attenuator of both mechanical and heat hypersensitivity induced by inflammatory and neuropathic pain models, the exact mechanism of action is as yet unknown Mechoulam and Hanus, ; Kress and Kuner, Unlike THC and related cannabinoids, phytocannabinoid-CBD, an important bioactive component of Cannabis sativa without psychotropic effect, is an antagonist of orphan G protein-coupled receptor 55 GPR55, a potential third metabotropic cannabinoid receptor without binding to CB1 and CB2 receptors Begg et al.
A particular focus has been on TRPA1 and TRPV1, two widely co-expressed ion channels found in CGRP expressing peptidergic nociceptors essential for neurogenic inflammation, oedema formation and inflammation-induced mechanical and thermal hypersensitivity Davis et al. Their activation by CBD in vitro results in desensitized responses following noxious stimulation with capsaicin or mustard oil, their respective agonists.
This mechanism potentially decreases neuropeptide expression Bisogno et al. In vivo absence or inhibition of TRPA1 results in reduced mechanical hypersensitivity in animal models of inflammation Petrus et al. Absence of TRPV1 in vivo reduces inflammation-induced swelling, thermal hypersensitivity and nociceptive behaviour in various pain models Caterina et al. In naive animals, TRPV1 immunoreactivity is localized in nociceptive primary afferents innervating the knee joint. After inflammation, TRPV1 expression increases not only in primary afferents, but is detected in synoviocytes which secrete lubricating fluid into the synovial space and function as local immune cells Kochukov et al.
Primary afferents are thus not only sensitized by peripheral release of pro-inflammatory cytokines, but are surrounded by cells that produce and release these molecules themselves. Further studies are needed to identify specific receptors and mechanisms underlying the anti-inflammatory and anti-hyperalgesic effects of CBD.
Transdermal CBD application was successful in decreasing monoarthritis-associated increases of pro-inflammatory biomarkers in neuronal tissues. In this study, the expression of CGRP in spinal cord was increased after peripheral inflammation as previously reported Sluka and Westlund, , and was decreased by high doses 6.
Like other neuropeptides, CGRP is rapidly transported to nerve terminals for release centrally as well as peripherally where as a potent vasodilator it contributes to neurogenic inflammation Kawasaki et al.
Although increases in CGRP are described in DRG after hindpaw inflammation Nahin and Byers, , no significant changes in DRG expression were observed here data not shown , possibly due to the small number of sensory neurons innervating the joint.
It is also plausible that by 7 days post monoarthritis induction, neuropeptide content has stabilized. In monoarthritic animals, spinal cord OX42 expression is increased in activated microglia, the immune cells specific to the central nervous system, as previously described for CFA-induced ankle inflammation and trinitrobenzene sulfonic acid TNBS -induced pancreatitis Shan et al.
Treatment with high doses of transdermal CBD in this study effectively reduced OX42 expression below baseline levels, indicating reduced microglial activation. CBD is a known non-psychoactive cannabinoid, and due to its low affinity for the CB1 receptor it would be expected that exploratory behavioural activity would be similar among treatment groups compared to negative side-effects associated with THC Croxford, ; Malone et al.
This was demonstrated in this study by lack of CBD-induced changes in open-field exploration among naive treatment groups. Combinatorial with psychoactivity, side-effects such as hypothermia and hypomobility induced by THC are avoided with use of CBD Zimmer et al. These studies demonstrate transdermal administration of CBD has long-lasting therapeutic effects without psychoactive side-effects.
Thus, use of topical CBD has potential as effective treatment of arthritic symptomatology. The data presented suggest transdermal CBD is a good candidate for developing improved therapies for these debilitating disease. Stinchcomb, University of Kentucky start-up funds to K.
Westlund and All-Tranz, Inc. Cannabidiol was a generous gift provided by NIDA. National Center for Biotechnology Information , U. Author manuscript; available in PMC Jul 1. Hammell , 1, a L.
The Topical Benefits of CBD
What are the topical uses of CBD Cream & CBD lotion? CBD and cannabis products made for skin application have a wide possibility of use. Similarly, the compounding effects of THC and CBD work together to the bloodstream to produce its euphoric effects, applying it topically. Topical CBD oil is packed with natural anti-inflammatory When it's applied to inflamed skin, you may experience satisfactory relief.