Topical steroidHighest potency Augmented betamethasone dipropionate: Apply bid [tape] Halobetasol propionate: Medium potency Betamethasone valerate: Highest potency Super potent Group 2: High potency Group 3:
Corticosteroids (Topical) 7 Group Classification
Highest potency Augmented betamethasone dipropionate: Apply bid [tape] Halobetasol propionate: Medium potency Betamethasone valerate: Highest potency Super potent Group 2: High potency Group 3: Medium potency Group 5: Low Mild potency Group 7: With chronic conditions, gradual discontinuation of therapy may reduce the chance of rebound.
Topical corticosteroids have anti-inflammatory, antipruritic and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid.
Arachidonic acid is released from membrane phospholipids by phospholipase A2. The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle and the integrity of the epidermal barrier. Occlusive dressings with hydrocortisone for up to 24 hours have not been demonstrated to increase penetration; however, occlusion of hydrocortisone for 96 hours markedly enhances penetration.
Topical corticosteroids can be absorbed from normal intact skin. The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. GlobalRPH does not directly or indirectly practice medicine or provide medical services and therefore assumes no liability whatsoever of any kind for the information and data accessed through the Service or for any diagnosis or treatment made in reliance thereon.
Medical Calculators - A thru Z. Lab Values - A thru Z. This site complies with the HONcode standard for trustworthy health information: Original Topical Corticosteroid Reference.
Highest potency Super potent. Corticosteroid strength has been classified according to the vasoconstrictor assay, which is based on the extent to which the compound induces cutaneous vasoconstriction "blanching effect" in normal human subjects.
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