Testosterone Therapy Side Effects vs Benefits OverviewFrom the book "Testosterone: A Man's Guide" by expert Nelson Vergel. Now available at Defy Medical. One of the main side effects of testosterone replacement therapy TRT is the reduced size of testicles in men. But there is something that can be done about this problem that most men on TRT do not know. HCG, a peptide used in fertility, has been shown to do help prevent testicular atrophy shrinkage. Human chorionic gonadotropin HCG not to be confused with human test prop t bol cycle hormone, or HGH is a hormone that mimics LH luteinizing hormoneproduced in pregnancy by the developing embryo soon hcg for low testosterone side effects conception, and later by hcg for low testosterone side effects of the placenta.
How to reverse the main side effect of Testosterone Therapy
From the book "Testosterone: A Man's Guide" by expert Nelson Vergel. Now available at Defy Medical. One of the main side effects of testosterone replacement therapy TRT is the reduced size of testicles in men. But there is something that can be done about this problem that most men on TRT do not know. HCG, a peptide used in fertility, has been shown to do help prevent testicular atrophy shrinkage.
Human chorionic gonadotropin HCG not to be confused with human growth hormone, or HGH is a hormone that mimics LH luteinizing hormone , produced in pregnancy by the developing embryo soon after conception, and later by part of the placenta. Its role is to prevent the disintegration of the corpus luteum of the ovary and to maintain the progesterone production critical for pregnancy in women.
HCG is used to cause ovulation and to treat infertility in women. But in men, HCG is also used in young boys when their testicles have not dropped down into the scrotum normally.
Additionally, HCG is used to increase testicular size after long-term testosterone. As mentioned at the beginning of the book, testosterone replacement therapy triggers the hypothalamus to shut down its production of GnRH gonadotropin releasing hormone. Without LH the testicles shut down their production of testosterone and the Leydig cells that produce testosterone start to hibernate and shrink in volume.
If the testicles have shrunken after long-term testosterone use, they will likely begin to enlarge and start their testosterone production shortly after HCG therapy is instituted. Also, the HCG doses required would make it an expensive option as a only way to boost testosterone. For that reason, several physicians are prescribing it in low doses along with testosterone injections and gels. Many insurance policies do not pay for HCG since they consider its use for testicular atrophy while on TRT an off label use.
So, most men using it for testicular atrophy pay for it out of their own pockets. It comes with bacteriostatic water for reconstitution. A review of the literature reveals a wide range of doses of HCG used with very little agreement among physicians. For male infertility, doses range from IU three times weekly to IU twice weekly these studies did not include men on testosterone replacement.
Currently there are no HCG guidelines for men who need to be on testosterone replacement therapy and want to maintain normal testicular size. A study that used mg per week of testosterone enanthate injections with HCG at doses of , , or IU every other day in healthy younger men showed that the IU dose every other day preserved normal testicular function. Another study recently published used a dose of HCG of IUs every other day along with TRT in an older group of men showed good preservation of testicular function, size and sperm count.
Due to its effect on testosterone, HCG use can also increase estradiol and DHT, so it is important to have these monitored by a physician. The best dose of HCG to sustain normal testicular function while keeping estradiol and DHT conversion to a minimum has not been established. Different men respond differently due to age and other issues. Some doctors are recommending using — IUs twice a week for men who are concerned about testicular size or who want to preserve fertility while on testosterone replacement.
Higher doses, such as 1,—5, IUs twice a week, have been used but I believe that these higher doses could cause more estrogen and DHT-related side effects, and possibly desensitize the testicles for HCG in the long term this problem has not been reported in the literature. Some doctors check estradiol levels a month after this protocol is started to determine whether the use of the estrogen receptor modulators tamoxifen or anastrozole, is needed to counteract any increases in estradiol levels.
High estradiol can cause breast enlargement and water retention in men but it is important at the right blood levels to maintain bone and brain health. Some men have asked me why we cannot use HCG solely to make our own testicles produce testosterone without the use of TRT along with it. Using HCG as sole testosterone replacement option may not bring the same subjective benefit on sexual function as pure testosterone delivery systems do—even when similar serum androgen levels are produced from comparable baseline values.
But in excess, HCG can cause acne, water retention, moodiness, and gynecomastia breast enlargement in men. After reading this article, you probably agree with me that using HCG requires a lot of discipline since you have to remember to inject it weekly in addition to your weekly or bi-weekly testosterone injection.
But I know of many men who have that type of commitment since they do not want testicular size reduction. Many report further improvements in sexual drive and function after they start this therapy. If you have any questions about HCG or any other therapies, please call Nelson Vergel is available for health coaching.
Contact patient services if you would like to schedule your appointment or order your copy of his book, Testosterone: Click the button below to find out more information about Nelson Vergel and his books on Testosterone. How to reverse the main side effect of Testosterone Therapy. Complete the form below to receive a free consultation. Defy Medical Tampa, FL.
Subscribe to our Newsletter.