Capric acidLauric acid, or dodecanoic acid, is the main acid in coconut oil and in palm kernel oil, and is believed to have antimicrobial properties. It is a white, powdery solid with a faint odor of bay oil or soap. Lauric acid, although slightly irritating to mucous membranes, has a very low toxicity and so is used in many soaps and decanoic acid structure. Sodium decanoic acid structure sulfate is the most decanoic acid structure lauric-acid derived compound used for this purpose. Because lauric acid has a non-polar hydrocarbon tail and a polar carboxylic acid head, it test prop t bol cycle interact with polar solvents the most important being water as well as fats, allowing water to dissolve fats.
decanoic acid (CHEBI)
Human serum albumin HSA is an abundant plasma protein that is responsible for the transport of fatty acids. HSA also binds and perturbs the pharmacokinetics of a wide range of drug compounds. Binding studies have revealed significant interactions b Binding studies have revealed significant interactions between fatty acid and drug-binding sites on albumin but high-resolution structural information on ligand binding to the protein has been lacking.
We report here a crystallographic study of five HSA-fatty acid complexes formed using saturated medium-chain and long-chain fatty acids C A total of seven binding sites that are occupied by all medium-chain and long-chain fatty acids have been identified, although medium-chain fatty acids are found to bind at additional sites on the protein, yielding a total of 11 distinct binding locations.
Comparison of the different complexes reveals key similarities and significant differences in the modes of binding, and serves to rationalise much of the biochemical data on fatty acid interactions with albumin. The two principal drug-binding sites, in sub-domains IIA and IIIA, are observed to be occupied by fatty acids and one of them in IIIA appears to coincide with a high-affinity long-chain fatty acid binding site.
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