The benefits and risks of testosterone replacement therapy: a reviewThe findings come in the last four studies to be reported out of the Testosterone Trials, a set of seven overlapping federally testosterone replacement therapy benefits and potential harms year-long clinical trials conducted at 12 sites across the United States. All told, the Testosterone Trials seem to indicate that the best use of ad therapy is for treatment of decreased sexual tren prohormone pct in men with so-called " low T " low testosterone levelstestosterone dangers side effects Dr. He is a Yale University professor of geriatrics who ran one of the clinical trial sites. But tsetosterone trials also found that men receiving testosterone treatment experienced a significantly greater increase feplacement arterial plaque than men not taking the hormone, Gill noted. That could raise their future risk of heart attackstroke and heart disease. The use of testosterone-replacement therapy has nearly doubled in recent years, testosterone replacement therapy benefits and potential harms 1. Food and Drug Administration.
What are the benefits and risks of testosterone therapy? Studies investigate
Log in with your Medical News Today account to create or edit your custom homepage, catch-up on your opinions notifications and set your newsletter preferences.
Sign up for a free Medical News Today account to customize your medical and health news experiences. Four of the studies document the effects of testosterone treatment on bone density , anemia , cognitive function , and the buildup of coronary plaque.
The fifth study is observational and examines the links between testosterone treatment and overall cardiovascular health. Researchers from the Perelman School of Medicine at the University of Pennsylvania, together with 12 medical centers across the United States, have conducted seven clinical trials in partnership with the National Institute on Aging.
The Testosterone Trials TTrials examined the effect of testosterone treatment on men aged 65 and over who had shown decreased levels of the sex hormone.
The results of the first three of the seven trials showed an improvement in all the aspects of sexual function and overall mood, and were published last year. The recently published JAMA studies conclude the research. The TTrials analyzed a total of 51, men and selected participants whose age-related testosterone levels were low enough to qualify for the studies.
The participants were then randomly divided into two groups: The testosterone dosage was adjusted to maintain normal levels for young men. Researchers then tested the efficacy of the treatment every 3 months. The trials were double-blinded, meaning neither the experimenters nor the participants knew which group was a placebo and which received the treatment. For the bone density and strength study, researchers used quantitative computed tomography to assess spine and hip bone mineral density at baseline and a year later.
To test cognition, researchers administerd a delayed paragraph recall test. They also assessed the visual memory, executive function, and spatial ability of the participants. To determine coronary artery plaque volume, researchers used a coronary computed tomographic angiography. The cardiovascular health study was observational, using Cox proportional hazard models to study associations between testosterone treatment and various cardiovascular health outcomes. These included acute myocardial infarction, angina , stroke , transient ischemic attack , as well as sudden cardiac death.
The trials showed that testosterone treatment improves bone mineral density and estimated bone strength, although a larger-scale, longer trial is needed to assess if the treatment also lowers the risk of fractures.
The treatment also improved hemoglobin levels in participants who had anemia, whether its causes were known or not. The trial reported an almost 40 percent higher increase in hemoglobin levels in participants who had taken testosterone, compared with the placebo group. Testosterone corrected both unexplained anemia , as well as anemia induced by an iron deficiency. However, testosterone did not seem to benefit memory or improve any other aspect of cognitive functioning.
Lastly, the trial for cardiovascular health revealed more coronary artery plaque buildup in testosterone-treated men compared with the placebo group. Those treated had a greater increase in the volume of noncalcified plaque than the control group. However, researchers note that larger studies are needed to fully understand the clinical significance of these studies. Additionally, the cardiovascular health observational study found that the risk of negative cardiovascular events was lower among the testosterone-treated group, compared with the control group, over a median follow-up period of 3.
Snyder, a professor of Medicine in the Division of Endocrinology, Diabetes, and Metabolism at the University of Pennsylvania, cautions that the findings suggest the treatment may pose a cardiovascular risk.
However, he also notes that "treating men for 1 year is far too few to draw conclusions about the clinical significance of the increase in coronary artery plaque volume and the cardiovascular risk of testosterone treatment. However, the increase of plaque buildup in the coronary artery shows that this treatment may also have some risk. Snyder also suggests future testosterone treatments should balance the health benefits with the risks.
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