3-keto-steroid reductaseIn addition to reproductive tissue, sex hormones induce transcriptional events in 3-kdtosteroid connective tissue cells, including osteoblasts. Some sex hormone receptor modulators with bone sparing effects selectively target estrogen reduuctase androgen receptors, whereas others appear more promiscuous, in part through enzymatic metabolism. Rat osteoblasts express the 3-ketosteroid reductase AKR1C9, 3-ketosteroid reductase aldo-keto reductase gene family member. Through these enzymes, they may selectively metabolize precursor compounds into potent steroid receptor 3-ketostreoid locally within bone. Several enzyme groups are known to modify sex steroids or their precursors in specific ways, and consequently control their 3-ketosteroid reductase to bind to and drive gene expression by discrete sex steroid receptors SSRs. Certain AKR family members exhibit distinct preferences for individual test prop t bol cycle or reaction direction, related to structural aspects of the substrate itself, to the redox 3-ketosteroid reductase, or to specific cofactor concentrations 1 3-ketosteroid reductase 6.
3-Ketosteroid Reductase Activity and Expression by Fetal Rat Osteoblasts
Systems used to automatically annotate proteins with high accuracy:. Select item s and click on "Add to basket" to create your own collection here entries max. Comprehensive resource for the study of protein post-translational modifications PTMs in human, mouse and rat. Additionally, this section gives relevant information on each alternative protein isoform. Align Add to basket Added to basket. This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it.
This is also the sequence that appears in the downloadable versions of the entry. The sequence of this isoform differs from the canonical sequence as follows: You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser. Your basket is currently empty. Reviewed - Annotation score: Select a section on the left to see content. View all proteins of this organism that are known to be involved in the pathway estrogen biosynthesis and in Steroid biosynthesis.
Proteins known to be involved in the 6 steps of the subpathway in this organism are: View all proteins of this organism that are known to be involved in the subpathway that synthesizes zymosterol from lanosterol , the pathway zymosterol biosynthesis and in Steroid biosynthesis.
Estradiol beta-dehydrogenase 7 EC: Endoplasmic reticulum endoplasmic reticulum membrane Source: Reactome Plasma Membrane plasma membrane Source: Drug and drug target database More Polymorphism and mutation databases BioMuta curated single-nucleotide variation and disease association database More Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea. Weakly expressed in all other tissues tested. Isoform 3 is expressed in eye ciliary epithelial cells and neuroendocrine cells.
Protein interaction database and analysis system More Chemistry databases BindingDB database of measured binding affinities More Database of comparative protein structure models More Align Add to basket Added to basket Isoform 1 identifier: It is useful for tracking sequence updates. The algorithm is described in the ISO standard. EMBL nucleotide sequence database More These are stable identifiers and should be used to cite UniProtKB entries.
P Secondary accession number s: Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest. Priority is given to the annotation of physiological ligands. Proton acceptor By similarity. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.
Lipid biosynthesis , Lipid metabolism , Steroid biosynthesis. Reactome - a knowledgebase of biological pathways and processes More Biochemical Reaction Kinetics Database More SwissLipids knowledge resource for lipid biology More Four distinct tokens exist: It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.
They may also represent different stages in a genome project and include components such as contigs, scaffolds or Whole Genome Shotgun WGS master records. Eukaryotic Pathogen Database Resources More Human Gene Nomenclature Database More It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.
BioMuta curated single-nucleotide variation and disease association database More Encyclopedia of Proteome Dynamics More PaxDb, a database of protein abundance averages across all three domains of life More CleanEx database of gene expression profiles More Genevisible search portal to normalized and curated expression data from Genevestigator More Human Protein Atlas More BindingDB database of measured binding affinities More Non-supervised Orthologous Groups More Eukaryotic Ortholog Groups More Database of Orthologous Groups More Database for complete collections of gene phylogenies More TreeFam database of animal gene trees More Integrated resource of protein families, domains and functional sites More Pfam protein domain database More View protein in Pfam PF Protein Motif fingerprint database; a protein domain database More Superfamily database of structural and functional annotation More These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples.
Sequence conflicts are usually of unknown origin. The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence s for display. Missing in isoform 2.
Missing in isoform 3. Select the link destinations: UniGene gene-oriented nucleotide sequence clusters More Ensembl eukaryotic genome annotation project More Kyoto Encyclopedia of Genes and Genomes More UCSC genome browser More Homo sapiens Human Chlorocebus sabaeus Green monkey Cercopithecus sabaeus Pan troglodytes Chimpanzee Macaca mulatta Rhesus macaque Gorilla gorilla gorilla Western lowland gorilla Rhinopithecus bieti Black snub-nosed monkey Pygathrix bieti Papio anubis Olive baboon Colobus angolensis palliatus Peters' Angolan colobus Rhinopithecus roxellana Golden snub-nosed monkey Pygathrix roxellana Mandrillus leucophaeus Drill Papio leucophaeus And more.
Homo sapiens Human Chlorocebus sabaeus Green monkey Cercopithecus sabaeus Macaca mulatta Rhesus macaque Pan troglodytes Chimpanzee Gorilla gorilla gorilla Western lowland gorilla Papio anubis Olive baboon Rhinopithecus bieti Black snub-nosed monkey Pygathrix bieti Nomascus leucogenys Northern white-cheeked gibbon Hylobates leucogenys Mandrillus leucophaeus Drill Papio leucophaeus Rhinopithecus roxellana Golden snub-nosed monkey Pygathrix roxellana And more.
Comparative Toxicogenomics Database More The Gene Wiki collection of pages on human genes and proteins More ProtoNet; Automatic hierarchical classification of proteins More P Primary citable accession number: This is version of the entry and version 1 of the sequence. Chordata Protein Annotation Program. Any medical or genetic information present in this entry is provided for research, educational and informational purposes only.
It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.